Targeting Bcl-2 protein in treatment of melanoma still requires further clarifications
نویسندگان
چکیده
منابع مشابه
Targeting Bcl-2/Bcl-XL Induces Antitumor Activity in Uveal Melanoma Patient-Derived Xenografts
PURPOSE Uveal melanoma (UM) is associated with a high risk of metastases and lack of efficient therapies. Reduced capacity for apoptosis induction by chemotherapies is one obstacle to efficient treatments. Human UM is characterized by high expression of the anti-apoptotic protein Bcl-2. Consequently, regulators of apoptosis such as Bcl-2 family inhibitors may constitute an attractive approach t...
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ing this work to humans. First, we do not know whether the molar concentration of CD3 is similarly limiting for the expression of transgenic human TCRs. If CD3 is indeed limiting, then the enhanced expression and functionality we achieve by cotransfection of CD3 and TCRs may be accompanied by enhanced toxicity. Thus, enhanced expression may increase the risk of mispairing of endogenous and tran...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2008
ISSN: 0923-7534
DOI: 10.1093/annonc/mdn672